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When changing any transdermal patch, patients should remove the old patch carefully, fold it in half with the adhesive sides together, and dispose of it safely according to the medication guide—typically in a sealed container out of reach of children and pets
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A further dimension emerged in May 2026, when the ATTAIN-MAINTAIN trial, published in Nature Medicine , found that patients who switched to orforglipron after achieving substantial weight loss on injectable GLP-1s maintained approximately 75–80% of that weight reduction
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