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The proposed mechanisms include GLP-1 mediated changes in blood pressure regulation, effects on retinal and optic nerve blood flow, and potential interactions with cardiovascular risk factors that are common in the populations taking these drugs

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These include people with a history of pancreatitis (since both alcohol and GLP-1 drugs stress the pancreas), those with liver disease or cirrhosis, individuals with a personal or family history of alcohol misuse, and patients with type 1 or type 2 diabetes who are also taking insulin or other glucose-lowering medications