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GLP-1s are also not appropriate for : Individuals who are underweight or undernourished Those at risk for sarcopenia (muscle loss) People with low muscle mass or nutritional deficiencies Adults over 65 with osteopenia, osteoporosis, or a recent history of fractures In these cases, reduced appetite and unintended weight loss can accelerate muscle and bone loss, making close medical supervision essential

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​ Most patients improve by eating enough protein, staying hydrated, avoiding extreme calorie restriction, and keeping light activity in their routine